The magic bullet: Niclosamide

H Jiang, AM Li, J Ye - Frontiers in Oncology, 2022 - frontiersin.org
The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …

Deciphering the Warburg effect: metabolic reprogramming, epigenetic remodeling, and cell dedifferentiation

AM Li, J Ye - Annual Review of Cancer Biology, 2024 - annualreviews.org
A century ago, Otto Heinrich Warburg made a seminal discovery now known as the Warburg
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …

Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells

H Jiang, CJ He, AM Li, B He, Y Li, MN Zhou… - Molecular Cancer …, 2023 - AACR
When the electron transport chain (ETC) function is impaired, cancer cells rely on reductive
carboxylation (RC) to convert α-ketoglutarate (αKG) to citrate for macromolecular synthesis …

Self-Delivery Nanoplatform Based on Amphiphilic Apoptosis Peptide for Precise Mitochondria-Targeting Photothermal Therapy

X Wan, W Wang, Y Zhou, X Ma, M Guan… - Molecular …, 2024 - ACS Publications
Mitochondria-targeting photothermal therapy could significantly enhance the tumor cell
killing effect. However, since therapeutic reagents need to overcome a series of …

Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes

BN Gantner, FR Palma, MR Pandkar, MJ Sakiyama… - Trends in Cancer, 2024 - cell.com
Emerging evidence indicates that metabolism not only is a source of energy and
biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment …

Salicylanilides and their anticancer properties

T Kauerová, MJ Pérez-Pérez, P Kollar - International Journal of Molecular …, 2023 - mdpi.com
Salicylanilides are pharmacologically active compounds with a wide spectrum of biological
effects. Halogenated salicylanilides, which have been used for decades in human and …

Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response

M Failli, S Demir, Á Del Río-Álvarez… - Hepatology, 2024 - journals.lww.com
Hepatology AASLD Publications Hepatology Liver Transplantation Clinical Liver Disease
Hepatology Communications Log in or Register Subscribe to journalSubscribe Get new issue …

[HTML][HTML] SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant …

L Zhang, Z Dai, S Shi, Z Yan, J Yang, W Xue… - Biochemical …, 2024 - Elsevier
Tumor cells with damaged mitochondria undergo metabolic reprogramming, but gene
therapy targeting mitochondria has not been comprehensively reported. In this study …

Defining neuroblastoma: From origin to precision medicine

L Sainero-Alcolado, T Sjöberg Bexelius… - Neuro …, 2024 - academic.oup.com
Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is
the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous …

The Warburg effect drives dedifferentiation through epigenetic reprogramming

H Jiang, M Jedoui, J Ye - Cancer Biology & Medicine, 2024 - pmc.ncbi.nlm.nih.gov
German biochemist and cell physiologist, Otto H. Warburg (Figure 1), made a
groundbreaking discovery in 1923. Specifically, tumors were shown to consume large …