Peptide self-assembly through liquid-liquid phase separation
C Yuan, Q Li, R Xing, J Li, X Yan - Chem, 2023 - cell.com
Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …
research model to understand life phenomena but also for constructing sophisticated …
Peptide self-assembly: thermodynamics and kinetics
J Wang, K Liu, R Xing, X Yan - Chemical Society Reviews, 2016 - pubs.rsc.org
Self-assembling systems play a significant role in physiological functions and have therefore
attracted tremendous attention due to their great potential for applications in energy …
attracted tremendous attention due to their great potential for applications in energy …
Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors
Alzheimer's disease (AD) is characterized by an imbalance between production and
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Systems chemistry of peptide-assemblies for biochemical transformations
During the billions of years of the evolutionary journey, primitive polymers, involved in proto
metabolic pathways with low catalytic activity, played critical roles in the emergence of …
metabolic pathways with low catalytic activity, played critical roles in the emergence of …
Chiral self-assembly of peptides: Toward the design of supramolecular polymers with enhanced chemical and biological functions
Chirality is one of the most important structural features in biological systems. Peptides, as a
class of small biomolecules, can self-assemble into various chiral supramolecular polymers …
class of small biomolecules, can self-assemble into various chiral supramolecular polymers …
Structural studies of amyloid proteins at the molecular level
DS Eisenberg, MR Sawaya - Annual review of biochemistry, 2017 - annualreviews.org
Dozens of proteins are known to convert to the aggregated amyloid state. These include
fibrils associated with systemic and neurodegenerative diseases and cancer, functional …
fibrils associated with systemic and neurodegenerative diseases and cancer, functional …
Catalytic diversity in self-propagating peptide assemblies
The protein-only infectious agents known as prions exist within cellular matrices as
populations of assembled polypeptide phases ranging from particles to amyloid fibres …
populations of assembled polypeptide phases ranging from particles to amyloid fibres …
Metal-ion modulated structural transformation of amyloid-like dipeptide supramolecular self-assembly
The misfolding of proteins and peptides potentially leads to a conformation transition from an
α-helix or random coil to β-sheet-rich fibril structures, which are associated with various …
α-helix or random coil to β-sheet-rich fibril structures, which are associated with various …