Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
The complement system
JV Sarma, PA Ward - Cell and tissue research, 2011 - Springer
The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …
important role in host defense and inflammation. Complement activation results in …
Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the …
S Yalavarthi, TJ Gould, AN Rao, LF Mazza… - Arthritis & …, 2015 - Wiley Online Library
Objective Antiphospholipid antibodies (aPL), especially those targeting β2‐glycoprotein I
(β2GPI), are well known to activate endothelial cells, monocytes, and platelets, with …
(β2GPI), are well known to activate endothelial cells, monocytes, and platelets, with …
Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
L Dejager, I Pinheiro, E Dejonckheere, C Libert - Trends in microbiology, 2011 - cell.com
Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …
Molecular intercommunication between the complement and coagulation systems
U Amara, MA Flierl, D Rittirsch, A Klos… - The Journal of …, 2010 - journals.aai.org
The complement system as well as the coagulation system has fundamental clinical
implications in the context of life-threatening tissue injury and inflammation. Associations …
implications in the context of life-threatening tissue injury and inflammation. Associations …
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …
Rationale for targeting complement in COVID‐19
A Polycarpou, M Howard, CA Farrar… - EMBO molecular …, 2020 - embopress.org
A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread
internationally, posing a health emergency to the global community. COVID‐19 caused by …
internationally, posing a health emergency to the global community. COVID‐19 caused by …
The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
The complement system: history, pathways, cascade and inhibitors
P Nesargikar, B Spiller, R Chavez - European Journal of …, 2012 - akjournals.com
Since its discovery in the 19th century, the complement system has developed into a
clinically significant entity. The complement system has been implicated in a variety of …
clinically significant entity. The complement system has been implicated in a variety of …
Role of C5a in inflammatory responses
RF Guo, PA Ward - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The complement system not only represents an effective innate immune
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …
mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in …