[HTML][HTML] Molecular aspects of furocoumarin reactions: Photophysics, photochemistry, photobiology, and structural analysis

N Kitamura, S Kohtani, R Nakagaki - Journal of Photochemistry and …, 2005 - Elsevier
The photophysics, photochemistry, photobiology, and structural analysis of furocoumarin
derivatives have been reviewed from molecular and interdisciplinary points of view. The …

Warfarin: history, tautomerism and activity

WR Porter - Journal of computer-aided molecular design, 2010 - Springer
The anticoagulant drug warfarin, normally administered as the racemate, can exist in
solution in potentially as many as 40 topologically distinct tautomeric forms. Only 11 of these …

Separation of drug stereoisomers by the formation of β-cyclodextrin inclusion complexes

DW Armstrong, TJ Ward, RD Armstrong, TE Beesley - Science, 1986 - science.org
For many drugs, only racemic mixtures are available for clinical use. Because different
stereoisomers of drugs often cause different physiological responses, the use of pure …

The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling

A Mancy, P Broto, S Dijols, PM Dansette… - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received May 15, 1995® abstract; Biochemical experiments, usingthe
well-defined human liver CYP2C9 expressed in yeast, and molecular modeling techniques …

Structure of warfarin in solution

EJ Valente, EC Lingafelter, WR Porter… - Journal of medicinal …, 1977 - ACS Publications
Warfarin in solution is shownto consist of three interconverting tautomeric structures, two of
which are cyclic diastereomeric hemiketals, while the third and minor component is the open …

The spectrophysics of warfarin: Implications for protein binding

BCG Karlsson, AM Rosengren… - The Journal of …, 2007 - ACS Publications
The photophysical behavior of the isomers of the anticoagulant drug warfarin in various
solvents and solvent mixtures was investigated using absorption, 1H NMR, and steady-state …

Lanthanide and transition metal complexes of bioactive coumarins: Molecular modeling and spectroscopic studies

I Georgieva, T Mihaylov, N Trendafilova - Journal of Inorganic Biochemistry, 2014 - Elsevier
The present paper summarizes theoretical and spectroscopic investigations on a series of
active coumarins and their lanthanide and transition metal complexes with application in …

Structural requirements for substrates of cytochromes P-450 and P-448

DFV Lewis, C Ioannides, DV Parke - Chemico-biological interactions, 1987 - Elsevier
Distinct and different molecular structural features are manifested by substrates, inhibitors
and inducers of the two families of liver microsomal enzymes, the phenobarbital-induced …

Dissolution and ionization of warfarin

VJ Stella, KG Mooney, JD Pipkin - Journal of pharmaceutical sciences, 1984 - Elsevier
It has been shown in recent studies that warfarin exists in the solid state and in some
nonaqueous solvents as a cyclic hemiketal. The present study was undertaken to investigate …

4‐Hydroxycoumarin/2‐hydroxychromone tautomerism: Infrared spectra of 2‐13c and 3‐D labeled 4‐hydroxycoumarin and its anion

AO Obaseki, WR Porter… - Journal of Heterocyclic …, 1982 - Wiley Online Library
Bands with primarily v (C= O) and v (C= O) character in the spectra of 4‐hydroxycoumarin
and its anion were identified by isotopic substitution with either 13C or deuterium. Two …