Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …

A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich
base side chains at the C2 position, which possess dual asexual blood and sexual stage …

Malaria cases and deaths keep being excessively high every year. Some inroads gained in
the last two decades have been eroded especially due to the surge of resistance to most …

Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue
1 with an associated metabolic instability liability led to the identification of a highly potent 3 …

Objectives The principal objectives of this review were to gather information on the potential
role of antihistamines as anti-infective agents and to identify the gaps in research that have …

The fascinating and dangerous colored pathogens contain unique chemically pigmented
molecules, which give varied and efficient assistance as virulence factors to the crucial …

Herein, a metal-free and solvent-free protocol was developed for the C–N coupling of
heteroaryl halides and amines, which afforded numerous heteroaryl amines or their …

Malaria control programs continue to be threatened by drug resistance. To identify new
antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based …