Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

The system of assigning locus symbols to specify chromosomal regions that are associated
with a familial disorder has a number of problems when used as a reference list of …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Genes for familial hemiplegic migraine (FHM) and episodic ataxia type-2 (EA-2) have been
mapped to chromosome 19p13. We characterized a brain-specific P/Q-type Ca 2+ channel …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Idiopathic generalized epilepsies account for about 40% of epilepsy up to age 40 and
commonly have a genetic basis. One type is benign familial neonatal convulsions (BFNC), a …

Benign familial neonatal convulsions (BFNC) is an autosomal dominant epilepsy of infancy,
with loci mapped to human chromosomes 20q13. 3 and 8q24. By positional cloning, a …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …