UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Background. Phase II biotransformation reactions (also 'conjugation reactions') generally
serve as a detoxifying step in drug metabolism. Phase II drug metabolising enzymes are …

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases,
have been identified in the human, mouse and rat genomes and in other mammalian …

Purpose In this study we characterized the genetic variability of 146 clinically relevant genes
influencing drug pharmacokinetics in African and European subpopulations, which are key …

UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …

Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of
carcinogens that are formed during the combustion of tobacco or during the high …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Green tea is one of the most popular beverages worldwide. Its major components include (-)-
epicatechin ((-)-EC),(-)-epicatechin-3-gallate (ECG)(-)-epigallocatechin (EGC) and (-) …