TBX5: a key regulator of heart development

JD Steimle, IP Moskowitz - Current topics in developmental biology, 2017 - Elsevier
TBX5 is a member of the T-box transcription factor family and is primarily known for its role in
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …

Potential clinical implications of miR-1 and miR-21 in heart disease and cardioprotection

B Kura, B Kalocayova, Y Devaux… - International journal of …, 2020 - mdpi.com
The interest in non-coding RNAs, which started more than a decade ago, has still not
weakened. A wealth of experimental and clinical studies has suggested the potential of non …

Genetics and epigenetics of atrial fibrillation

E Lozano-Velasco, D Franco, A Aranega… - International journal of …, 2020 - mdpi.com
Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …

MicroRNAs in atrial fibrillation: from expression signatures to functional implications

NWE van den Berg, M Kawasaki, WR Berger… - … Drugs and Therapy, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with
pronounced morbidity and mortality. Its prevalence, expected to further increase for the …

Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms

M Vinciguerra, D Dobrev, S Nattel - The Lancet Regional Health …, 2024 - thelancet.com
Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of
the general population. Its prevalence dramatically increases with age and could reach up …

Multiple roles of Pitx2 in cardiac development and disease

D Franco, D Sedmera, E Lozano-Velasco - Journal of cardiovascular …, 2017 - mdpi.com
Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic
mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these …

Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human

X Kang, Y Zhao, G Van Arsdell, SF Nelson, M Touma - Rna, 2020 - rnajournal.cshlp.org
Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators and play
important roles in cardiac development and congenital heart disease. In a previous study …

Upregulation of miR-133b and miR-328 in patients with atrial dilatation: implications for stretch-induced atrial fibrillation

M Mase, M Grasso, L Avogaro… - Frontiers in …, 2019 - frontiersin.org
Atrial stretch and dilatation are common features of many clinical conditions predisposing to
atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants …

Non-coding RNAs and atrial fibrillation

D Franco, A Aranega, JN Dominguez - Non-coding RNAs in …, 2020 - Springer
Atrial fibrillation is the most frequent type of cardiac arrhythmia in humans, with an estimate
incidence of 1–2% in the general population, rising up to 8–10% in the elderly …

[HTML][HTML] A narrative review of non-coding RNAs in atrial fibrillation: Potential therapeutic targets and molecular mechanisms

L Zhang, X Wang, C Huang - Annals of translational medicine, 2021 - ncbi.nlm.nih.gov
Objective This review summarizes the advances in the study of ncRNAs and atrial
remodeling mechanisms to explore potential therapeutic targets and strategies for AF …