Trending topics on coumarin and its derivatives in 2020
Coumarins are naturally occurring molecules with a versatile range of activities. Their
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
Umbelliferone and its synthetic derivatives as suitable molecules for the development of agents with biological activities: a review of their pharmacological and …
A Kornicka, Ł Balewski, M Lahutta, J Kokoszka - Pharmaceuticals, 2023 - mdpi.com
Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a
naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that …
naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that …
Cucurbit [7] uril macrocyclic sensors for optical fingerprinting: predicting protein structural changes to identifying disease-specific amyloid assemblies
In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …
pattern of chemical and topological features, which are altered during its misfolding and …
Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …
play key roles in inflammation and cancer. Current strategies to develop small molecule …
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer …
The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …
Allosteric inhibitors of macrophage migration inhibitory factor (MIF) Interfere with Apoptosis-Inducing factor (AIF) Co-Localization to prevent Parthanatos
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential
signaling protein associated with inflammation and cancers. One of the newly described …
signaling protein associated with inflammation and cancers. One of the newly described …
Activity-Based Imaging of Macrophage Migration Inhibitory Factor with a Two-Photon Fluorescent Probe
X Wang, X Wang, Y Liu, Z Sun, H Liu, J Shen… - ACS …, 2022 - ACS Publications
Macrophage migration inhibitory factor (MIF), as a cytokine, plays an important role in the
pathogenesis of cancer and some other diseases, and it is also one of the potential drug …
pathogenesis of cancer and some other diseases, and it is also one of the potential drug …
Small molecule mif modulation enhances ferroptosis by impairing DNA repair mechanisms
D Chen, C Zhao, J Zhang, CWJ Knol… - Advanced …, 2024 - Wiley Online Library
Ferroptosis is a form of regulated cell death that can be modulated by small molecules and
has the potential for the development of therapeutics for oncology. Although excessive lipid …
has the potential for the development of therapeutics for oncology. Although excessive lipid …
Cellular membrane imaging of the dynamic binding-dissociation of rhodamine-benzenesulfonamide bioconjugate with carbonic anhydrase IX for inhibitor screening
W Zhou, Q Qiao, Y Tao, W Jiang, X Fang, J Li… - Sensors and Actuators B …, 2023 - Elsevier
Fluorescent displacement assay has been used as an effective method to screen target
protein inhibitors, but there is a lack of reports on the detection of small molecule inhibitor …
protein inhibitors, but there is a lack of reports on the detection of small molecule inhibitor …
[HTML][HTML] HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway
Non-small-cell lung carcinoma (NSCLC) is one of the most common forms of lung cancer,
and a leading cause of cancer death among human beings. There is an urgent demand for …
and a leading cause of cancer death among human beings. There is an urgent demand for …