Recreational and chronic cannabis use has been associated with a range of acute and
chronic effects including; anti‐nociceptive actions, anxiety, depression, psychotic symptoms …

The recent shift in socio-political debates and growing liberalization of Cannabis use across
the globe has raised concern regarding its impact on vulnerable populations such as …

Increased cannabis availability has contributed to increased use with concomitant incidence
of adverse effects. One risk factor for adverse drug reactions may be age. There is preclinical …

Long-term use of potent cannabis during adolescence increases the risk of developing
schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several …

The use of cannabis for animal species is an area of growing interest, largely due to the
therapeutic benefits being observed for humans and animals in the era of cannabis …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …

Cannabis and cannabinoids are increasingly being accessed and used by patients with
advanced cancer for various symptoms and general quality of life. Specific symptoms of …

Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an
earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5‐HT2AR) …

Membrane receptors often form complexes with other membrane proteins that directly
interact with different effectors of the signal transduction machinery. G-protein-coupled …

Abstract Endocannabinoid (eCB) and serotonin (5-HT) neuromodulatory systems work both
independently and together to finely orchestrate neuronal activity throughout the brain to …