Whipworm and roundworm infections

KJ Else, J Keiser, CV Holland, RK Grencis… - Nature Reviews …, 2020 - nature.com
Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal
dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a …

The immune response to nematode infection

M Stear, S Preston, D Piedrafita… - International Journal of …, 2023 - mdpi.com
Nematode infection is a major threat to the health of humans, domestic animals and wildlife.
Nematodes vary in their effect on the host and in the mechanisms underlying immunity but …

Whipworm secretions and their roles in host-parasite interactions

RK Shears, RK Grencis - Parasites & Vectors, 2022 - Springer
Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in
humans and animals. Of particular interest are T. trichiura, the causative agent of human …

Mining helminths for novel therapeutics

KE Lothstein, WC Gause - Trends in molecular medicine, 2021 - cell.com
Helminths are an emerging source of therapeutics for dysregulated inflammatory diseases.
Excretory/secretory (ES) molecules, released during infection, are responsible for many of …

Metabolomic profiling of the excretory–secretory products of hookworm and whipworm

P Wangchuk, K Kouremenos, RM Eichenberger… - Metabolomics, 2019 - Springer
Introduction Soil-transmitted helminths infect billions of people, livestock and companion
animals worldwide, and chronic infections with these nematodes represent a major health …

Etiology of colitis-complex diarrhea in growing pigs: a review

FM Panah, C Lauridsen, O Højberg, TS Nielsen - Animals, 2021 - mdpi.com
Simple Summary Diarrhea in growing pigs is a challenge for the pig industry since it is
associated with reduced animal welfare, retarded growth, increased feed conversion ratio …

Potential of human helminth therapy for resolution of inflammatory bowel disease: The future ahead

T Arai, F Lopes - Experimental Parasitology, 2022 - Elsevier
Inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune
response in the gastrointestinal tract. The number of patients with IBD has increased …

Mining nematode protein secretomes to explain lifestyle and host specificity

L Tritten, C Ballesteros, R Beech… - PLoS Neglected …, 2021 - journals.plos.org
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals
and plants. Despite great differences in their life cycles, host preference and transmission …

[HTML][HTML] Development of caecaloids to study host–pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the …

MA Duque-Correa, F Schreiber, FH Rodgers… - International Journal for …, 2020 - Elsevier
The caecum, an intestinal appendage in the junction of the small and large intestines,
displays a unique epithelium that serves as an exclusive niche for a range of pathogens …

Schistosome and intestinal helminth modulation of macrophage immunometabolism

D Cortes‐Selva, K Fairfax - Immunology, 2021 - Wiley Online Library
Macrophages are fundamental to sustain physiological equilibrium and to regulate the
pathogenesis of parasitic and metabolic processes. The functional heterogeneity and …