Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

The liver plays a key role in maintaining energy homeostasis by sensing and responding to
changes in nutrient status under various metabolic conditions. Recently highlighted as a …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight.
There is ongoing debate about the mechanisms that mediate metformin's effects on energy …

Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain.
Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and …

Background and aims Metformin, the most prescribed drug for the treatment of type 2
diabetes mellitus, has been recently reported to promote weight loss by upregulating the …

The interaction of exercise with appetite control and energy intake has been widely studied
due to the ability of exercise-related energy expenditure to influence energy and substrate …

Body weight is under physiological regulation. When body fat mass decreases, a series of
responses are triggered to promote weight regain by increasing food intake and decreasing …

Objective Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism
and circulating GDF15 increases in response to exercise. The source and regulation of the …

Introduction. Growth differentiation factor 15 (GDF‐15) has been shown to be a metabolic
and appetite regulator in diabetes mellitus (DM) and obesity. We aimed to investigate (i) the …