Partners in crime: beta-cells and autoimmune responses complicit in type 1 diabetes pathogenesis
E Toren, KLS Burnette, RR Banerjee… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …
The role of GLUT2 in glucose metabolism in multiple organs and tissues
B Sun, H Chen, J Xue, P Li, X Fu - Molecular biology reports, 2023 - Springer
The glucose transporter family has an important role in the initial stage of glucose
metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A …
metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A …
Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to chemotherapy by abrogating the TopBP1/ATR-mediated DNA damage response
L Ding, VS Madamsetty, S Kiers, O Alekhina… - Clinical Cancer …, 2019 - AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a predominantly fatal common
malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an …
malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an …
Glucose-dependent miR-125b is a negative regulator of β-cell function
R Cheung, G Pizza, P Chabosseau, D Rolando… - Diabetes, 2022 - Am Diabetes Assoc
Impaired pancreatic β-cell function and insulin secretion are hallmarks of type 2 diabetes.
miRNAs are short, noncoding RNAs that silence gene expression vital for the development …
miRNAs are short, noncoding RNAs that silence gene expression vital for the development …
High glucose‐mediated VPS26a down‐regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation
CW Chae, GE Choi, YH Jung, JR Lim… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose The relationship between hyperglycaemia‐induced retromer
dysfunction impairing intracellular trafficking and Alzheimer's disease (AD) remains unclear …
dysfunction impairing intracellular trafficking and Alzheimer's disease (AD) remains unclear …
Metabolic regulation through the endosomal system
J Gilleron, JM Gerdes, A Zeigerer - Traffic, 2019 - Wiley Online Library
The endosomal system plays an essential role in cell homeostasis by controlling cellular
signaling, nutrient sensing, cell polarity and cell migration. However, its place in the …
signaling, nutrient sensing, cell polarity and cell migration. However, its place in the …
Sorting out sorting nexins functions in the nervous system in health and disease
Endocytosis is a fundamental process that controls protein/lipid composition of the plasma
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes
Y Liu, J Deng, D Fan - Food and Chemical Toxicology, 2021 - Elsevier
The aim of this study is to investigate the hypoglycemic mechanism of ginsenoside Rh4 (G-
Rh4) in vivo and in vitro models. Our results showed that G-Rh4 markedly improved the …
Rh4) in vivo and in vitro models. Our results showed that G-Rh4 markedly improved the …
[HTML][HTML] 2-Hydroxylation is a chemical switch linking fatty acids to glucose-stimulated insulin secretion
H Li, L Lin, X Huang, Y Lu, X Su - Journal of Biological Chemistry, 2024 - jbc.org
Glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells is metabolically regulated
and progressively diminished during the development of type 2 diabetes (T2D). This …
and progressively diminished during the development of type 2 diabetes (T2D). This …
[HTML][HTML] Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice
A Heida, T van Dijk, M Smit, M Koehorst… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is a
pentameric protein complex localized at endosomes, where it facilitates the transport of …
pentameric protein complex localized at endosomes, where it facilitates the transport of …