Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

Evolving concepts on bradykinesia

M Bologna, G Paparella, A Fasano, M Hallett… - Brain, 2020 - academic.oup.com
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

The basal ganglia: focused selection and inhibition of competing motor programs

JW Mink - Progress in neurobiology, 1996 - Elsevier
The basal ganglia comprise several nuclei in the forebrain, diencephalon, and midbrain
thought to play a significant role in the control of posture and movement. It is well recognized …

Pathophysiology of bradykinesia in Parkinson's disease

A Berardelli, JC Rothwell, PD Thompson, M Hallett - Brain, 2001 - academic.oup.com
Bradykinesia means slowness of movement and is one of the cardinal manifestations of
Parkinson's disease. Weakness, tremor and rigidity may contribute to but do not fully explain …

Pathophysiology of spastic paresis. I: Paresis and soft tissue changes

JM Gracies - Muscle & Nerve: Official Journal of the American …, 2005 - Wiley Online Library
Spastic paresis follows chronic disruption of the central execution of volitional command.
Motor function in patients with spastic paresis is subjected over time to three fundamental …

A two‐year randomized controlled trial of progressive resistance exercise for Parkinson's disease

DM Corcos, JA Robichaud, FJ David… - Movement …, 2013 - Wiley Online Library
The effects of progressive resistance exercise (PRE) on the motor signs of Parkinson's
disease have not been studied in controlled trials. The objective of the current trial was to …

The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease

MA Hirsch, T Toole, CG Maitland, RA Rider - Archives of physical medicine …, 2003 - Elsevier
Hirsch MA, Toole T, Maitland CG, Rider RA. The effects of balance training and high-
intensity resistance training on persons with idiopathic Parkinson's disease. Arch Phys Med …

Direction-specific postural instability in subjects with Parkinson's disease

FB Horak, D Dimitrova, JG Nutt - Experimental neurology, 2005 - Elsevier
The purpose of this study was to determine whether and why subjects with Parkinson's
disease (PD) have greater instability in response to specific directions of perturbations than …

Forced, not voluntary, exercise improves motor function in Parkinson's disease patients

AL Ridgel, JL Vitek, JL Alberts - … and neural repair, 2009 - journals.sagepub.com
Background. Animal studies indicate forced exercise (FE) improves overall motor function in
Parkinsonian rodents. Global improvements in motor function following voluntary exercise …

High‐intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease

LE Dibble, TF Hale, RL Marcus, J Droge… - … : official journal of the …, 2006 - Wiley Online Library
Strength deficits in persons with Parkinson's disease (PD) have been identified as a
contributor to bradykinesia. However, there is little research that examines the effect of …