Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …

Nutrient handling by higher organisms is a complex process that is regulated at the
transcriptional level. Studies over the past 15 years have highlighted the critical importance …

A major challenge modern society has to face is the increasing need for tissue regeneration
due to degenerative diseases or tumors, but also accidents or warlike conflicts. There is …

Adipose tissue is a rich source of multipotent mesenchymal stem-like cells, located in the
perivascular niche. Based on their surface markers, these have been assigned to two main …

Stem cells are subdivided into two main categories: embryonic and adult stem cells. In
principle, pluripotent embryonic stem cells might differentiate in any cell types of the …

Obesity is a serious public health problem associated with predisposition to develop
metabolic diseases. Over the past decade, several studies in vitro and in vivo have shown …

Adenosine has broad activities in organisms due to the existence of multiple receptors, the
differential adenosine concentrations necessary to activate these receptors and the …

The high incidence of obesity has increased the need to discover new therapeutic targets to
combat obesity and obesity-related metabolic diseases. Obesity is defined as an abnormal …

Stem cell differentiation is determined by a repertoire of signals from its microenvironment,
which includes the extracellular matrix (ECM) and soluble cues. The ability of mesenchymal …

Mesenchymal stem cells (MSCs) play an important role in tissue homeostasis and damage
repair through their ability to differentiate into cells of different tissues, trophic support, and …