Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …

Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …

Tumour recurrence is a serious impediment to cancer treatment, but the mechanisms
involved are poorly understood. The most frequently used anti-tumour therapies …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an
atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies …

Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive
chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL …

Cellular senescence is a biological aging hallmark that plays a key role in the development
of neurodegenerative diseases. Clinical trials are currently underway to evaluate the …