The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management
continues to provide a unique and authoritative comparison of asthma and COPD. Written …

Background New evidence has suggested that people with asthma who are homozygous for
arginine at aminoacid 16 of the β 2-adrenergic receptor (ADRB2) might not benefit from …

Rationale: Several studies suggest that patients with asthma who are homozygous for
arginine at the 16th position of the β2-adrenergic receptor may not benefit from short-acting …

β-1 and β-2 adrenoceptors (AR) play a pivotal role in regulation of the activity of the
sympathetic nervous system and agonists and antagonists at both β AR subtypes are …

Rationale: The comprehensive evaluation of gene variation, haplotype structure, and
linkage disequilibrium is important in understanding the function of β2-adrenergic receptor …

The beta2-adrenergic receptor (beta2-AR) is a member of the G-protein-coupled adrenergic
receptor family with seven transmembrane segments. Similar to other members of this …

Background. About 9% of children have asthma, corresponding to almost 6.8 million
children in the USA and 1.1 million in the UK. Asthma exacerbations are the leading cause …

Identification of novel variants that contribute to response heterogeneity supports future
studies of single nucleotide polymorphism discovery and include gene expression and …

Summary Beta‐2‐Adrenergic receptors (β2AR) participate in the physiologic responses of
the lung, including bronchodilation and bronchoprotection, through mechanisms such as …

The most prescribed medication for controlling bronchoconstriction associated with asthma
and chronic obstructive pulmonary disease are β-agonists. The gene ADR β 2 encodes the …