Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of
great bedside relevance to practicing hepatologists. This evolution reflects growing awarenessnotonlyofthemolecularunderpinn …

Lung cancers are characterised by abundant genetic diversity with relatively few recurrent
mutations occurring at high frequency. However, the genetic alterations often affect a …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to
collagen accumulation during chronic liver disease. With increasing interest in developing …

Increased stromal collagen deposition in human breast tumours correlates with metastases.
We show that activation of the collagen I receptor DDR2 (discoidin domain receptor 2) …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …