Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

Type 1A topoisomerases (topos) are the only topos that bind single-stranded DNA and the
only ones found in all cells of the three domains of life. Two subfamilies, topo I and topo III …

Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational
biases that influence genome evolution and adaptation. How do such diverse biases …

Topoisomerase (Topo) accelerates cell growth and division, and has been a theoretical
target for anti-cancer drugs for decades. A series of pyridoxal thiosemicarbazone (PLT) …

Topoisomerases in the type IA subfamily can catalyze change in topology for both DNA and
RNA substrates. A type IA topoisomerase may have been present in a last universal …

Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable
target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks …

Antimicrobial resistance (AMR) studies of Mycoplasma bovis have generally focused on
specific loci versus using a genome-wide association study (GWAS) approach. A GWAS …

How do hierarchical gene regulation networks evolve in bacteria? Nucleoid-associated
proteins (NAPs) influence the overall structure of bacterial genomes, sigma factors and …

DNA methylation is one of the earliest discovered and most extensively studied epigenetic
regulatory mechanisms. Broadly, DNA methylation refers to the transfer of a methyl group on …

Biofilms are structured microbial communities that offer protection from a range of
environmental stressors. Studies of experimental evolution within biofilms have yielded …