The dark side of gamma-glutamyltransferase (GGT): Pathogenic effects of an 'antioxidant'enzyme

A Corti, E Belcastro, S Dominici, E Maellaro… - Free Radical Biology …, 2020 - Elsevier
Having long been regarded as just a member in the cellular antioxidant systems, as well as
a clinical biomarker of hepatobiliary diseases and alcohol abuse, gamma …

Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease

G Ndrepepa, R Colleran, A Kastrati - Clinica chimica acta, 2018 - Elsevier
Gamma-glutamyl transferase (GGT) is a ubiquitous cell surface enzyme that cleaves
extracellular glutathione (G-SH) or other gamma-glutamyl compounds. GGT serves to …

Gamma‐glutamyltransferase—friend or foe within?

SK Kunutsor - Liver International, 2016 - Wiley Online Library
Gamma‐glutamyltransferase (GGT) is a liver enzyme, which is located on the plasma
membranes of most cells and organ tissues, but more commonly in hepatocytes, and is …

[HTML][HTML] Gamma-glutamyl transferase and cardiovascular disease

G Ndrepepa, A Kastrati - Annals of translational medicine, 2016 - ncbi.nlm.nih.gov
Gamma-glutamyl transferase (GGT) is an enzyme located on the external surface of cellular
membranes. GGT contributes in maintaining the physiological concentrations of cytoplasmic …

The mercapturic acid pathway

PE Hanna, MW Anders - Critical reviews in toxicology, 2019 - Taylor & Francis
The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer

K Kawakami, Y Fujita, Y Matsuda, T Arai, K Horie… - BMC cancer, 2017 - Springer
Background Exosomes or extracellular vesicles have the potential as a diagnostic marker for
various diseases including cancer. In order to identify novel exosomal markers for prostate …

A systematic review of serum γ-glutamyltransferase as a prognostic biomarker in patients with genitourinary cancer

K Takemura, PG Board, F Koga - Antioxidants, 2021 - mdpi.com
γ-Glutamyltransferase (GGT), a membrane-bound enzyme, contributes to the metabolism of
glutathione (GSH), which plays a critical physiological role in protecting cells against …

Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) in serum: results from an IFCC …

F Ceriotti, J Henny, J Queraltó, S Ziyu… - Clinical chemistry and …, 2010 - degruyter.com
Background: Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-
glutamyl transferase (GGT) measurements are important for the assessment of liver damage …

[HTML][HTML] Role of gamma-glutamyltransferase in cardiovascular diseases

S Jiang, D Jiang, Y Tao - Experimental & Clinical Cardiology, 2013 - ncbi.nlm.nih.gov
Cardiovascular diseases are threatening human health with rising morbidity and mortality
rates. Gamma-glutamyltransferase (GGT) has been found to be involved in the pathogenesis …

Gamma-glutamyltransferase fractions in human plasma and bile: characteristic and biogenesis

I Fornaciari, V Fierabracci, A Corti, H Aziz Elawadi… - PLoS …, 2014 - journals.plos.org
Total plasma gamma-glutamyltransferase (GGT) activity is a sensitive, non-specific marker of
liver dysfunction. Four GGT fractions (b-, m-, s-, f-GGT) were described in plasma and their …