PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

Within the life cycle of a living organism, another life cycle exists for the selfish genome
inhabitants, which are called transposable elements (TEs). These mobile sequences invade …

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically
incurable. Defining the genetic basis of NOA has proven challenging, and the most …

PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are
significant in development and reproduction of organisms. Recently, emerging evidences …

PIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known
for their function in silencing transposons and germline development by partnering with …

Background Cervical cancer (CC) is one of the most common gynecological tumors that
threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is …