Macrophage activation highlight an important role for NER proteins in the survival, latency and multiplication of Mycobacterium tuberculosis
M Thakur, K Muniyappa - Tuberculosis, 2023 - Elsevier
Nucleotide excision repair (NER) is one of the most extensively studied DNA repair
processes in both prokaryotes and eukaryotes. The NER pathway is a highly conserved …
processes in both prokaryotes and eukaryotes. The NER pathway is a highly conserved …
Neisseria gonorrhoeae: DNA Repair Systems and Their Role in Pathogenesis
VY Savitskaya, MV Monakhova, IV Iakushkina… - Biochemistry …, 2022 - Springer
Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative
agent of gonorrhea, a sexually transmitted infection. The bacterium uses various …
agent of gonorrhea, a sexually transmitted infection. The bacterium uses various …
Developing novel antimicrobials by combining cancer chemotherapeutics with bacterial DNA repair inhibitors
Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
Antibacterial Activity and Mechanism of Action of Osthole against Listeria monocytogenes
Y Kong, H Yan, J Hu, Y Dang, Z Han… - Journal of Agricultural …, 2024 - ACS Publications
The purpose of this study was to investigate the antibacterial activity and mechanism of
action of osthole against Listeria monocytogenes. The antibacterial activity of osthole was …
action of osthole against Listeria monocytogenes. The antibacterial activity of osthole was …
Identification of a novel DNA repair inhibitor using an in silico driven approach shows effective combinatorial activity with genotoxic agents against multidrug‐resistant …
Increasing antimicrobial drug resistance represents a global existential threat. Infection is a
particular problem in immunocompromised individuals, such as patients undergoing cancer …
particular problem in immunocompromised individuals, such as patients undergoing cancer …
Combining cancer chemotherapeutics with bacterial DNA repair inhibitors to develop novel antimicrobials
Cancer chemotherapeutics kill rapidly dividing cells, which includes cells of the immune
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
system. The resulting neutropenia predisposes patients to infection, which delays treatment …
[HTML][HTML] Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome
NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …