Calcium (Ca2+) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the
cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion …

The 'building-block'model of inositol trisphosphate (IP3)-mediated Ca2+ liberation posits that
cell-wide cytosolic Ca2+ signals arise through coordinated activation of localized Ca2+ puffs …

Salivary fluid secretion involves an intricate choreography of membrane transporters to
result in the trans-epithelial movement of NaCl and water into the acinus lumen. Current …

The receptor-evoked Ca 2+ signal in secretory epithelia mediate many cellular functions
essential for cell survival and their most fundamental functions of secretory granules …

Abstract Inositol 1, 4, 5-trisphosphate (IP3) plays a key role in calcium signaling. After
stimulation, it diffuses from the plasma membrane where it is produced to the endoplasmic …

We have constructed a spatiotemporal model of Ca^ 2+ Ca 2+ dynamics in parotid acinar
cells, based on new data about the distribution of inositol trisphophate receptors (IPR). The …

Since the early seminal studies on epithelial solute transport, it has been understood that
there must be crosstalk among different members of the transport machinery to coordinate …

We construct a three-dimensional anatomically accurate multicellular model of a parotid
gland acinus to investigate the influence that the topology of its lumen has on primary fluid …

We present a computer-assisted approach to prove the existence of Hopf bubbles and
degenerate Hopf bifurcations in ordinary and delay differential equations. We apply the …

We consider a general model for intracellular calcium dynamics. This model has solutions
that evolve on multiple timescales, but cannot be written in the so-called standard form for …