[HTML][HTML] The hallmarks of aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …
function and increased vulnerability to death. This deterioration is the primary risk factor for …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
X Huang, H Zhang, X Guo, Z Zhu, H Cai… - Journal of hematology & …, 2018 - Springer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …
When stem cells grow old: phenotypes and mechanisms of stem cell aging
MB Schultz, DA Sinclair - Development, 2016 - journals.biologists.com
All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …
attractive theory is that a loss in stem cell number and/or activity over time causes this …
The role of miRNAs in regulating gene expression networks
AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …
species, expressed across cell types, and active against a large proportion of the …
[HTML][HTML] Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to
silence mRNA expression. Argonaute binding alters the properties of an RNA guide …
silence mRNA expression. Argonaute binding alters the properties of an RNA guide …
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
MR Copley, S Babovic, C Benz, DJHF Knapp… - Nature cell …, 2013 - nature.com
Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several
properties, including a marked reduction in their self-renewal activity. We now show that the …
properties, including a marked reduction in their self-renewal activity. We now show that the …
Adult-specific functions of animal microRNAs
K Sun, EC Lai - Nature reviews genetics, 2013 - nature.com
Abstract MicroRNAs (miRNAs) are~ 22 nt RNAs that coordinate vast regulatory networks in
animals and thereby influence myriad processes. This Review examines evidence that …
animals and thereby influence myriad processes. This Review examines evidence that …
Mechanisms that regulate stem cell aging and life span
RAJ Signer, SJ Morrison - Cell stem cell, 2013 - cell.com
Mammalian aging is associated with reduced tissue regeneration, increased degenerative
disease, and cancer. Because stem cells regenerate many adult tissues and contribute to …
disease, and cancer. Because stem cells regenerate many adult tissues and contribute to …