Advances in biomedical Raman microscopy

KA Antonio, ZD Schultz - Analytical chemistry, 2014 - ACS Publications
The vibrational modes of molecules provide an intrinsic contrast mechanism for identifying
components in cells, tissues, and organisms. When excited by a laser, Raman scattered …

New advances in probing cell–extracellular matrix interactions

AP Liu, O Chaudhuri, SH Parekh - Integrative Biology, 2017 - academic.oup.com
The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …

Stain-free histopathology by programmable supercontinuum pulses

H Tu, Y Liu, D Turchinovich, M Marjanovic… - Nature …, 2016 - nature.com
The preparation, staining, visualization and interpretation of histological images of tissue is
well accepted as the gold standard process for the diagnosis of disease. These methods …

Compact supercontinuum sources and their biomedical applications

A Labruyère, A Tonello, V Couderc, G Huss… - Optical Fiber …, 2012 - Elsevier
Recent developments of compact white-light supercontinuum laser sources are reviewed.
Basically these sources make use of a sub-nanosecond microchip laser and a photonic …

Circular dichroism microscopy free from commingling linear dichroism via discretely modulated circular polarization

T Narushima, H Okamoto - Scientific Reports, 2016 - nature.com
In this work, we developed a circular dichroism (CD) imaging microscope with a device to
suppress the commingling of linear birefringence (LB) and linear dichroism (LD) signals. CD …

Raman scattering: from structural biology to medical applications

AV Vlasov, NL Maliar, SV Bazhenov, EI Nikelshparg… - Crystals, 2020 - mdpi.com
This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural
biology, biophysics, cells, and tissues imaging towards development of various medical …

Near shot-noise limited hyperspectral stimulated Raman scattering spectroscopy using low energy lasers and a fast CMOS array

W Rock, M Bonn, SH Parekh - Optics Express, 2013 - opg.optica.org
We demonstrate near shot-noise limited hyperspectral stimulated Raman scattering (SRS)
spectroscopy using oscillator-only excitation conditions. Using a fast CMOS camera …

The chemical fingerprint of hair melanosomes by infrared nano-spectroscopy

V Stanic, FCB Maia, R de Oliveira Freitas, FE Montoro… - Nanoscale, 2018 - pubs.rsc.org
In situ characterization of the chemical and structural properties of black and white sheep
hair was performed with a spatial resolution of 25 nm using infrared nano-spectroscopy …

Hyperspectral coherent Raman imaging–principle, theory, instrumentation, and applications to life sciences

H Kano, H Segawa, M Okuno… - Journal of Raman …, 2016 - Wiley Online Library
Coherent Raman scattering microscopy such as coherent anti‐Stokes Raman scattering and
stimulated Raman scattering microscopy boosts the weak Raman signal and enables us to …

[HTML][HTML] Local structure of human hair spatially resolved by sub-micron X-ray beam

V Stanić, J Bettini, FE Montoro, A Stein… - Scientific reports, 2015 - nature.com
Human hair has three main regions, the medulla, the cortex and the cuticle. An existing
model for the cortex suggests that the α-keratin-based intermediate filaments (IFs) align with …