Contrary to their well-known functions in nutrient breakdown, mitochondria are also
important biosynthetic hubs and express an evolutionarily conserved mitochondrial fatty acid …

Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …

The mitochondrial genome, mtDNA, is present in multiple copies in cells and encodes
essential subunits of oxidative phosphorylation complexes. mtDNA levels have to change in …

The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and
genotype, and the phenotypic and evolutionary consequences of such variation, are poorly …

Cytonuclear interaction refers to the complex and ongoing process of coevolution between
nuclear and organelle genomes, which are responsible for cellular respiration …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction
associated with several diseases. Previous genome-wide association studies (GWAS) have …

Over the past decade, mtDNA-Server established itself as one of the most widely used
variant calling web-services for human mitochondrial genomes. The service accepts …

Mitochondria consist of hundreds of proteins, most of which are inaccessible to the
proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial …

Mutations of mitochondrial (mt) DNA are a major cause of morbidity and mortality in humans,
accounting for approximately two thirds of diagnosed mitochondrial disease. However …

Mitochondrial DNA (mtDNA), a multicopy genome found in mitochondria, is crucial for
oxidative phosphorylation. Mutations in mtDNA can lead to severe mitochondrial dysfunction …