Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis
M Schlesinger, G Bendas - Cancer and Metastasis Reviews, 2015 - Springer
The integrin “very late antigen-4”(VLA-4) is expressed by numerous cells of hematopoietic
origin and possesses a key function in the cellular immune response, eg, by mediating …
origin and possesses a key function in the cellular immune response, eg, by mediating …
Remarks on possible local parity violation in heavy ion collisions
In this Rapid Communication we discuss some observations concerning the possible local
parity violation in heavy ion collisions recently announced by the STAR Collaboration. Our …
parity violation in heavy ion collisions recently announced by the STAR Collaboration. Our …
Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera
CC Wang, C Biben, L Robb, F Nassir, L Barnett… - Developmental …, 2000 - Elsevier
Regulated emigration of blood-borne leukocytes plays a defining role in lymphoid organ
development, immune surveillance, and inflammatory responses. We report here that mice …
development, immune surveillance, and inflammatory responses. We report here that mice …
[HTML][HTML] α4β7 Integrin (LPAM-1) is upregulated at atherosclerotic lesions and is involved in atherosclerosis progression
K Zhi, M Li, X Zhang, Z Gao, J Bai, Y Wu… - Cellular Physiology and …, 2014 - karger.com
Background/Aims: Integrin activation and lymphocyte migration to the vascular intima is a
key event in early atherosclerosis. α4β7 integrin (LPAM-1) and its ligand, mucosal addressin …
key event in early atherosclerosis. α4β7 integrin (LPAM-1) and its ligand, mucosal addressin …
The β7 integrin gene (Itgb-7) promoter is responsive to TGF-β1: defining control regions
Abstract The β7 integrins LPAM-1 (α4β7) and M290 (αEβ7) mediate the homing of
lymphocytes to gut-associated lymphoid tissue, and the proposed retention of intraepithelial …
lymphocytes to gut-associated lymphoid tissue, and the proposed retention of intraepithelial …
Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis
G Halpert, T Eitan, E Voronov, RN Apte… - Journal of Biological …, 2014 - ASBMB
Inflammatory bowel diseases (IBDs) are a group of idiopathic, chronic immune-mediated
diseases characterized by an aberrant immune response, including imbalances of …
diseases characterized by an aberrant immune response, including imbalances of …
Efficient gene deletion of Integrin alpha 4 in primary mouse CD4 T cells using CRISPR RNA pair-mediated fragmentation
T Wi, Y Choi, J Kim, YS Choi, ME Pipkin… - Frontiers in …, 2024 - frontiersin.org
The functional specialization of CD4 T lymphocytes into various subtypes, including TH1
and TFH cells, is crucial for effective immune responses. TFH cells facilitate B cell …
and TFH cells, is crucial for effective immune responses. TFH cells facilitate B cell …
MAdCAM‐1 costimulates T cell proliferation exclusively through integrin α4β7, whereas VCAM‐1 and CS‐1 peptide use α4β1: evidence for “remote” costimulation …
K Lehnert, CG Print, Y Yang… - European journal of …, 1998 - Wiley Online Library
We have analyzed the effects of the α4 integrin ligands mucosal addressin cell adhesion
molecule‐1 (MAdCAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and the fibronectin …
molecule‐1 (MAdCAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and the fibronectin …
LPAM‐1 (integrin α4β7)‐ligand binding: overlapping binding sites recognizing VCAM‐1, MAdCAM‐1 and CS‐1 are blocked by fibrinogen, a fibronectin‐like polymer …
Y Yang, PM Cardarelli, K Lehnert… - European journal of …, 1998 - Wiley Online Library
Abstract The α4 integrin LPAM‐1 (α4β7) mediates lymphocyte attachment within the
extracellular matrix (ECM) by adhering to the connecting segment (CS)‐1 site of fibronectin …
extracellular matrix (ECM) by adhering to the connecting segment (CS)‐1 site of fibronectin …
α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin
H Ohmatsu, T Kadono, M Sugaya, M Tomita… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: β7 Integrin, a cell adhesion molecule, is present in the form of α4β7 integrin
or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their …
or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their …