Revisiting retinal degeneration hallmarks: insights from molecular markers and therapy perspectives

JGS Rosa, GR Disner, FJ Pinto, C Lima… - International Journal of …, 2023 - mdpi.com
Visual impairment and blindness are a growing public health problem as they reduce the life
quality of millions of people. The management and treatment of these diseases represent …

cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis

V Kumar, JH Stewart IV - International Journal of Molecular Sciences, 2024 - mdpi.com
Pattern recognition receptors (PRRs) recognize danger signals such as PAMPs/MAMPs and
DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, and RLRs are well …

Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation

S Yan, H Liang, P Zhan, H Zheng… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Declined skeletal muscle mass and function are inevitable consequences of
long‐term diabetes and bring about many adverse events. Muscle fibre atrophy and …

A new gene signature for endothelial senescence identifies self‐RNA sensing by retinoic acid‐inducible gene I as a molecular facilitator of vascular aging

J Guduric‐Fuchs, E Pedrini, PM Bertelli… - Aging …, 2024 - Wiley Online Library
The number of senescent vascular endothelial cells increases during aging and their
dysfunctional phenotype contributes to age‐related cardiovascular disease. Identification of …

Rejuvenation of diabetic macular edema with senolytic therapy

T Murakami, TW Gardner - Nature Medicine, 2024 - nature.com
Rejuvenation of diabetic macular edema with senolytic therapy | Nature Medicine Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol

Z Zheng, J Wang, J Lin, W Ye, J Zou, L Liang… - Acta Pharmacologica …, 2024 - nature.com
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are
prominent features of vascular aging and contribute to the development of aging-associated …

STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved …

Z Chen, X Li, X Sun, S Xiao, T Chen, L Ren… - Free Radical Biology and …, 2024 - Elsevier
Vascular calcification is a prevalent hallmark of cardiovascular risk in elderly and diabetic
individuals. Senescent vascular smooth muscle cells (VSMCs) participate in calcification; …

Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy

YS Shi, TN Yang, YX Wang, XY Ma, S Liu, Y Zhao… - Research, 2024 - spj.science.org
The accumulation of senescent cells in kidneys is considered to contribute to age-related
diseases and organismal aging. Mitochondria are considered a regulator of cell senescence …

Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway

L Liang, J Zeng, R Liu, Z Zheng, D Lyu, X Zhang… - Biochemical …, 2024 - Elsevier
Diabetic nephropathy (DN) is a complication of diabetes and is mainly characterized by
renal fibrosis, which could be attributed to chronic kidney inflammation. Stimulator of …

Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis

Z Chen, Y Cao, W Jiang, Z Yan, G Cai, J Ye… - Oral …, 2024 - Wiley Online Library
Objective This study aimed to assess the effects of Porphyromonas gingivalis outer
membrane vesicles (Pg‐OMVs) in chronic periodontitis and explore the underlying …