Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Cells are highly dynamic and mechanical automata powered by molecular motors that
respond to external cues. Intracellular signaling pathways, either chemical or mechanical …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

Disulfide bonds represent versatile posttranslational modifications whose roles encompass
the structure, catalysis, and regulation of protein function. Due to the oxidizing nature of the …

Constitutive activation of nuclear factor kappa B (NF-κB) has been linked with
carcinogenesis and cancer progression, including metastasis, chemoresistance, and …

Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

The significant influence of tumor microenvironment on malignant cells has been
investigated with enthusiasm in this era of targeted therapy. Transglutaminase 2 (TG2, EC …

Tissue transglutaminase (transglutaminase type 2; TG2) is the most ubiquitously expressed
member of the transglutaminase family (EC 2.3. 2.13) that catalyzes specific post …

Cervical carcinoma is the second most common cause of cancer deaths in women
worldwide. Treatments have not changed for decades and survival rates for advanced …

Type II transglutaminase (TG2) is a multifunctional protein that has recently been implicated
as having a role in ECS cell survival. In the present study we investigate the role of TG2 in …