SARS-CoV-2: immunity, challenges with current vaccines, and a novel perspective on mucosal vaccines

R Sunagar, A Singh, S Kumar - Vaccines, 2023 - mdpi.com
The global rollout of COVID-19 vaccines has played a critical role in reducing pandemic
spread, disease severity, hospitalizations, and deaths. However, the first-generation …

Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®)

C Singh, S Verma, P Reddy, MS Diamond, DT Curiel… - npj Vaccines, 2023 - nature.com
One of the most preferable characteristics for a COVID-19 vaccine candidate is the ability to
reduce transmission and infection of SARS-CoV-2, in addition to disease prevention. Unlike …

[HTML][HTML] A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines

JME Lim, SK Hang, S Hariharaputran, A Chia… - Cell Reports …, 2022 - cell.com
Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell …

T-cell immunity to SARS-CoV-2: what if the known best is not the optimal course for the long run? Adapting to evolving targets

AE Nowill, M Caruso, PO de Campos-Lima - Frontiers in immunology, 2023 - frontiersin.org
Humanity did surprisingly well so far, considering how unprepared it was to respond to the
coronavirus disease 2019 (COVID-19) threat. By blending old and ingenious new …

Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

S Rakshit, S Babji, C Parthiban, R Madhavan, V Adiga… - npj Vaccines, 2023 - nature.com
Detailed characterisation of immune responses induced by COVID-19 vaccines rolled out in
India: COVISHIELDTM (CS) and COVAXIN®(CO) in a pre-exposed population is only …

Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike …

J Sembera, C Baine, V Ankunda, JS Katende… - Frontiers in …, 2023 - frontiersin.org
Introduction This study investigated the antibody responses to the inactivated COVID-19
vaccine, CoronaVac (Sinovac Biotech) in the African population to provide valuable insights …

SARS-CoV-2-neutralizing antibody response and correlation of two serological assays with microneutralization

A Souiri, S Lemriss, B El Maliki, H Falahi, E El Fahime… - Vaccines, 2023 - mdpi.com
SARS-CoV-2 has caused a huge pandemic affecting millions of people and resulting
innumerous deaths. A better understanding of the correlation between binding antibodies …

Acceptance of COVID-19 vaccine booster dose among the people of Bangladesh: A cross-sectional study

DN Roy, S Ali, AK Sarker, E Islam, MS Azam - Heliyon, 2023 - cell.com
Vaccine booster dose (VBD) provides a potential therapeutic alliance in preventing
breakthrough infection and new variant's arrival while preserving long-lasting host immunity …

[HTML][HTML] Elevated neutralization of Omicron with sera of COVID-19 recovered and breakthrough cases vaccinated with Covaxin than two dose naïve vaccinees

PD Yadav, GN Sapkal, RR Sahay, DY Patil… - The Journal of …, 2022 - ncbi.nlm.nih.gov
In a recent systemic literature review, Walsh et al. reported that viral load of severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) peaks around symptom onset, and …

Effects of negative attitudes towards vaccination in general and trust in government on uptake of a booster dose of COVID-19 vaccine and the moderating role of …

X Ye, HH Lee, KH Hui, M Xin, PKH Mo - Vaccines, 2023 - mdpi.com
Uptake of a booster dose of COVID-19 vaccine is effective in preventing infection and severe
consequences caused by COVID-19. The present study examined the effects of negative …