The impact of light-sheet fluorescence microscopy (LSFM) is visible in fields as diverse as
developmental and cell biology, anatomical science, biophysics and neuroscience …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass,
the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS) …

During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

How organ-shaping mechanical imbalances are generated is a central question of
morphogenesis, with existing paradigms focusing on asymmetric force generation within …

Moving cells can sense and respond to physical features of the microenvironment; however,
in vivo, the significance of tissue topography is mostly unknown. Here, we used Drosophila …

Mechanical stress can influence cell proliferation in vitro, but whether it makes a significant
contribution to growth control in vivo, and how it is modulated and experienced by cells …

The sculpting of embryonic tissues and organs into their functional morphologies involves
the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in …

Light-sheet fluorescence microscopy (LSFM) methods collectively represent the major
breakthrough in developmental bio-imaging of living multicellular organisms. They are …

Organ architecture is often composed of multiple laminar tissues arranged in concentric
layers. During morphogenesis, the initial geometry of visceral organs undergoes a …