The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …

Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …

Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While …

Summary The term 'neuromyelitis optica'('Devic's syndrome', NMO) refers to a syndrome
characterized by optic neuritis and myelitis. In recent years, the condition has raised …

Background Serum autoantibodies against the water channel aquaporin-4 (AQP4) are
important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO) …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

Antibodies to aquaporin‐4 (called NMO‐IgG or AQP4‐Ab) constitute a sensitive and highly
specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential …