Melatonin is well known for its circadian production by the pineal gland, and there is a
growing body of data showing that it is also produced by many other cells and organs …

Circadian timekeeping is a ubiquitous mechanism that enables organisms to maintain
temporal coordination between internal biological processes and time of the local …

MiRNAs are increasingly recognized as biomarkers for the diagnosis of cancers where they
are profiled from tumor tissue (intracellular miRNAs) or serum/plasma samples (extracellular …

Biological rhythms control the life of virtually all organisms, impacting numerous aspects
ranging from subcellular processes to behaviour. Many studies have shown that changes in …

While endogenous lipids are known to exhibit rhythmic oscillations, less is known about how
specific lipids modulate circadian behavior. Through a series of loss-of-function and gain-of …

Circadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin
production is primarily regulated by circadian regulation of gene expression and is involved …

The circadian rhythm (CR) is a set of autonomous endogenous oscillators. Exposure to the
24-hour day-night cycle synchronizes our CR system, maintaining homeostasis and human …

The endogenous circadian timekeeping system drives~ 24-h rhythms in gene expression
and rhythmically coordinates the physiology, metabolism and behavior in a wide range of …

Background Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with high
morbidity and mortality rates. Oxidative stress and inflammation are important pathological …

By regulating the timing of cellular processes, the circadian clock provides a way to adapt
physiology and behaviour to the geophysical time. In mammals, a light-entrainable master …