The mechanism (s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary …

A Hunyadi - Medicinal research reviews, 2019 - Wiley Online Library
Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

Reductive metabolites of curcumin and their therapeutic effects

A Pandey, M Chaturvedi, S Mishra, P Kumar… - Heliyon, 2020 - cell.com
Curcumin, a secondary metabolite from the turmeric plant is one of the most promising
natural products, which has been studied extensively for decades. It has demonstrated …

Molecular targets of curcumin in breast cancer

X Song, M Zhang, E Dai, Y Luo - Molecular Medicine …, 2019 - spandidos-publications.com
Abstract Curcumin (diferuloylmethane), an orange‑yellow component of turmeric or curry
powder, is a polyphenol natural product isolated from the rhizome of Curcuma longa. For …

Curcumin and its nano-formulations: Defining triple-negative breast cancer targets through network pharmacology, molecular docking, and experimental verification

Z Deng, G Chen, Y Shi, Y Lin, J Ou, H Zhu… - Frontiers in …, 2022 - frontiersin.org
Background: Curcumin (CUR) displays the capability of suppressing the proliferation and
metastasis of various cancer cells. However, the effects and underline mechanisms of CUR …

[HTML][HTML] Therapeutic potential and limitations of curcumin as antimetastatic agent

P Dytrych, Z Kejík, J Hajduch, R Kaplánek… - Biomedicine & …, 2023 - Elsevier
Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

VK Singh, D Arora, MI Ansari… - Phytotherapy …, 2019 - Wiley Online Library
Naturally occurring phytochemicals or plant derivatives are now being explored extensively
for their health's benefits and medicinal uses. The therapeutic effect of phytochemicals has …

Dietary polyphenols for managing cancers: What have we ignored?

X Wu, M Li, Z Xiao, M Daglia, S Dragan… - Trends in Food Science …, 2020 - Elsevier
Although the chemoprevention and anti-cancer activities of dietary polyphenols have been
evidenced through both in vitro and in vivo studies, most of the human clinical trials were …

Two independent sulfation processes regulate mouth-form plasticity in the nematode Pristionchus pacificus

S Namdeo, E Moreno, C Rödelsperger… - …, 2018 - journals.biologists.com
Sulfation of biomolecules, like phosphorylation, is one of the most fundamental and
ubiquitous biochemical modifications with important functions during detoxification. This …

Utility of Intravenous Curcumin Nanodelivery Systems for Improving In Vivo Pharmacokinetics and Anticancer Pharmacodynamics

M Bagheri, CF van Nostrum, RJ Kok… - Molecular …, 2022 - ACS Publications
Curcumin nanoformulations for intravenous injection have been developed to offset poor
absorption, biotransformation, degradation, and excessive clearance associated with …

Effects of Curcumin on Tobacco Smoke‐induced Hepatic MAPK Pathway Activation and Epithelial–Mesenchymal Transition In Vivo

Z Liang, R Wu, W Xie, C Xie, J Wu, S Geng… - Phytotherapy …, 2017 - Wiley Online Library
Tobacco smoke is a major risk factor for hepatic cancer. Epithelial–mesenchymal transition
(EMT) induced by tobacco smoke is crucially involved in the initiation and development of …