Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Ebselen is an organoselenium compound exhibiting hydroperoxide-and peroxynitrite-
reducing activity, acting as a glutathione peroxidase and peroxiredoxin enzyme mimetic …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and
peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes …

Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …

Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria,
peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure …

Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as
lung allergens and irritants. Exposure to these substances can lead to inflammatory …

As aerobic organisms, we are continuously and throughout our lifetime subjected to an
oxidizing atmosphere and, most often, to environmental threats. The lung is the internal …

Background Pulmonary fibrosis is a major category of end-stage changes in lung diseases,
characterized by lung epithelial cell damage, proliferation of fibroblasts, and accumulation of …

Glutathione is a major redox buffer, reaching millimolar concentrations within cells and high
micromolar concentrations in airways. While glutathione has been traditionally known as an …