This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

More than 20 years after the identification of the sigma receptors as a unique binding site in
the brain and in the peripheral organs, several questions regarding this receptor are still …

Abstract The selective σ compound (+)-pentazocine was radiolabeled and its binding
characteristics in guinea pig brain membranes were investigated.[3 H](+)-Pentazocine …

The binding profiles of SA4503 (1-(3, 4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine
dihydrochloride), a novel σ receptor ligand, to σ1 and σ2 receptor subtypes in guinea pig …

抄録 Neuroactive neurosteroids, including progesterone, allopregnanolone, pregnenolone
and dehydroepiandrosterone, represent steroid hormones synthesized de novo in the brain …

Sigma (σ) receptors have generated a great deal of interest on the basis of their possible
role in psychosis and on locomotor behaviors. The effects of σ drugs on these various …

Behavioral models used to test potential antidepressants have shown that ligands that bind
to sigma receptors possess “antidepressant-like” properties. The focus of this review is to …

Drugs such as phencyclidine (PCP) that interact with PCP and sigma binding sites can
produce psychotomimetic effects that resemble some symptoms of schizophrenia. Therefore …

The immobility time in the mouse forced swimming test was dose-dependently reduced by
σ1 receptor agonists, such as 1-(3, 4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine …

1 Receptor‐mediated modulation of ion channels generally involves G‐proteins,
phosphorylation, or both in combination. The sigma receptor, which modulates voltage …