CRISPR-Cas based virus detection: Recent advances and perspectives

L Yin, S Man, S Ye, G Liu, L Ma - Biosensors and Bioelectronics, 2021 - Elsevier
Viral infections are one of the most intimidating threats to human beings. One convincing
example is the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. Rapid …

CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases

G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy

Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics

W Liu, L Li, J Jiang, M Wu, P Lin - Precision clinical medicine, 2021 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems
(Cas) are efficient tools for targeting specific genes for laboratory research, agricultural …

Ready for repair? Gene editing enters the clinic for the treatment of human disease

MPT Ernst, M Broeders, P Herrero-Hernandez… - … Therapy Methods & …, 2020 - cell.com
We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …

A nuclear export signal is required for cGAS to sense cytosolic DNA

H Sun, Y Huang, S Mei, F Xu, X Liu, F Zhao, L Yin… - Cell Reports, 2021 - cell.com
Summary The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates
STING-dependent signaling to produce type I interferons through synthesizing the …

[HTML][HTML] Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

S Najafi, SC Tan, S Aghamiri, P Raee… - Biomedicine & …, 2022 - Elsevier
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …

Detection methods for foodborne viruses: Current state-of-art and future perspectives

L Yin, Y Li, W Zhang, X Han, Q Wu, Y Xie… - Journal of Agricultural …, 2023 - ACS Publications
Foodborne viruses have been recognized as important threats to food safety and human
health. Rapid and accurate detection is one of the most crucial measures for food safety …

CRISPR-Cas13a inhibits HIV-1 infection

L Yin, F Zhao, H Sun, Z Wang, Y Huang, W Zhu… - … Therapy-Nucleic Acids, 2020 - cell.com
CRISPR-Cas provides bacteria and archaea with immunity against invading phages and
foreign plasmid DNA and has been successfully adapted for gene editing in a variety of …

CRISPR/Cas9: a tool to eradicate HIV-1

R Bhowmik, B Chaubey - AIDS Research and Therapy, 2022 - Springer
The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …