Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …

Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly
implicated in protein aggregation and toxicity which manifest in a number of neurological …

Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While
cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic …

Locus coeruleus (LC) is the main noradrenergic (NA) nucleus of the central nervous system.
LC degenerates early during Alzheimer's disease (AD) and NA loss might concur to AD …

Background The role of sex hormones on cellular function is unclear. Studies show
androgens and estrogens are protective in the CNS, whereas other studies found no effects …

The noradrenergic theory of Cognitive Reserve (Robertson, 2013–2014) postulates that the
upregulation of the locus coeruleus—noradrenergic system (LC–NA) originating in the …