A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Recent studies have profiled the innate immune signatures in patients infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

African swine fever virus (ASFV) is a highly pathogenic swine DNA virus with high mortality
that causes African swine fever (ASF) in domestic pigs and wild boars. For efficient viral …

The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

Since December 2019, humankind has been experiencing a ravaging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus …

SARS-CoV-2 is a positive sense RNA coronavirus that constitutes a new threat for the global
community and economy. While vaccines against SARS-CoV-2 are being developed, the …

The World Health Organization (WHO) announced in March a pandemic caused by Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This new infectious disease was …

Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the
immune response. While for decades the field isolated lytic capability and viral spread to …