The proteasome is the main proteolytic machinery of the cell and constitutes a recognized
drugable target, in particular for treating cancer. It is involved in the elimination of misfolded …

Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends
lifespan in invertebrates, including yeast, nematodes and fruitflies,,,,; however, whether …

The functional and therapeutic importance of the Warburg effect is increasingly recognized,
and glycolysis has become a target of anticancer strategies. We recently reported the …

Abstract According to the World Symposium Pulmonary Hypertension (WSPH) classification,
pulmonary hypertension (PH) is classified into five categories based on etiology. Among …

The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many
processes in cells in response to mitogens and variations in nutrient availability. Here we …

Abstract Background Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline
mutations in the BHD tumor suppressor gene that are associated with an increased risk for …

Metformin is the most frequently prescribed drug for type 2 diabetes. In addition to its
hypoglycemic effects, metformin also lowers cancer incidence. This anti-cancer activity is …

Background A growing body of evidence suggests that microRNAs (miRNAs) play an
important role in cancer diagnosis and therapy. MicroRNA-99a (miR-99a), a potential tumor …

Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor known to
regulate many cellular processes, including cell proliferation, transformation, invasion, and …

Constitutive autophagy is important for the control of the quality of proteins and organelles to
maintain cell function. Damaged proteins and organelles accumulate in aged organs. The …