In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

This review aims to cement three hot topics in drug delivery:(a) the pre-formulation of new
products intended for nose-to-brain delivery;(b) the development of nasal casts for studying …

How human respiratory physiology and the transport phenomena associated with inhaled
airflow in the upper airway proceed to impact transmission of SARS-CoV-2, leading to the …

Acetylcholinesterase inhibitors are the most used drugs to manage Alzheimer's disease,
although they show low bioavailability in the brain. In this sense, nasal administration has …

Deposition of polydisperse particles representing nasal spray application in a human nasal
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …

An idealized nasal replica that mimics average regional deposition of nasal spray pump
droplets in human nasal airways would potentially be useful in expediting the development …

Conductive olfaction and nose to brain drug delivery are important processes that remain
limited by inadequate odorant or drug delivery to the olfactory airspace. Primary challenges …

Computational fluid dynamics (CFD) allows quantitative assessment of transport
phenomena in the human nasal cavity, including heat exchange, moisture transport, odorant …

This study presents a novel coupled computational fluid dynamics-discrete element method
(CFD-DEM) model for simulating airflow and inhaled particle dynamics in the nasal cavity …

Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …