Novel therapies for the prevention of fibrosis in glaucoma filtration surgery

CG Shao, NR Sinha, RR Mohan, AD Webel - Biomedicines, 2023 - mdpi.com
Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration
surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but …

Delivering active molecules to the eye; the concept of electrospinning as potent tool for drug delivery systems

PI Siafaka, EÖ Bülbül, AN Miliotou, ID Karantas… - Journal of Drug Delivery …, 2023 - Elsevier
Ocular drug delivery is a challenging but fascinating topical route of administration. Although
the eye is easily accessible to common drug formulations such as drops, its complex …

In Situ Gelling Electrospun Ocular Films Sustain the Intraocular Pressure-Lowering Effect of Timolol Maleate: In Vitro, Ex Vivo, and Pharmacodynamic Assessment

II Andreadis, C Karavasili, A Thomas… - Molecular …, 2021 - ACS Publications
Most common intraocular pressure (IOP) reduction regimens for the management of
glaucoma include the topical use of eye drops, a dosage form that is associated with short …

Microfluidics in the eye: a review of glaucoma implants from an engineering perspective

Z Fang, S Bi, JD Brown, J Chen, T Pan - Lab on a Chip, 2023 - pubs.rsc.org
Glaucoma is a progressive optic neuropathy in the eye, which is a leading cause of
irreversible blindness worldwide and currently affects over 70 million individuals. Clinically …

Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior

A Josyula, A Mozzer, J Szeto, Y Ha… - Bioengineering & …, 2023 - Wiley Online Library
Biomaterials are implanted in millions of individuals worldwide each year. Both naturally
derived and synthetic biomaterials induce a foreign body reaction that often culminates in …

Effectiveness and biocompatibility of a novel Schlemm's canal microstent for glaucoma management

M Huang, Y Zhang, Z Chen, C Liu, J Wang, X Feng… - Scientific Reports, 2024 - nature.com
To evaluate the effectiveness and biocompatibility of Wistend, a novel Schlemm's canal (SC)
microstent made of Nitinol designed to improve aqueous humor outflow. New Zealand white …

A New Polymeric Minimally Invasive Glaucoma Implant

ICF Pereira, PAA Bartels, CJF Bertens… - Advanced Materials …, 2024 - Wiley Online Library
Glaucoma drainage devices are implanted in the eye to treat glaucoma, a disease that can
cause vision loss and blindness. These devices are designed to reduce intraocular pressure …

Effective Needleless Electrospinning for the Production of Tubular Scaffolds

A Klapstova, P Honzikova, M Dasek… - ACS Applied …, 2024 - ACS Publications
This review is devoted to the development of a technique for the fabrication of tubular
samples based on needleless electrospinning. Such materials have the potential for use in a …

新型纳米材料在青光眼诊疗中的研究进展.

卢彦霏, 原慧萍 - Chinese Journal of Ophthalmology & …, 2024 - search.ebscohost.com
青光眼是导致视力丧失的主要原因之一, 其诊疗仍存在诸多困难, 如持续眼压监测,
抗青光眼药物制剂的副作用和长期应用以及引流物植入术后的并发症等. 纳米材料因其具有尺寸 …

Animal Model Contributions to Primary Congenital Glaucoma

Q Xia, D Zhang, Y Zhuang, Y Dai, H Jia… - Journal of …, 2022 - Wiley Online Library
Primary congenital glaucoma (PCG) is an ocular disease characterized by congenital
anterior segmental maldevelopment with progressive optic nerve degeneration. Certain …