[HTML][HTML] In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review
Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …
step in the early stages of drug discovery. In particular, the absorption of orally administered …
Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies
S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
BCS class IV drugs: Highly notorious candidates for formulation development
BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …
exhibit many characteristics that are problematic for effective oral and per oral delivery …
Oral delivery of anticancer drugs: challenges and opportunities
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …
significance of oral delivery in cancer therapeutics has been highlighted which principally …
The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability
The oral bioavailability of a health-promoting dietary component (nutraceutical) may be
limited by various physicochemical and physiological phenomena: liberation from food …
limited by various physicochemical and physiological phenomena: liberation from food …
Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research
The implementation of microfluidic devices within life sciences has furthered the possibilities
of both academic and industrial applications such as rapid genome sequencing, predictive …
of both academic and industrial applications such as rapid genome sequencing, predictive …
Biomimetic tissues on a chip for drug discovery
AM Ghaemmaghami, MJ Hancock, H Harrington… - Drug discovery today, 2012 - Elsevier
Developing biologically relevant models of human tissues and organs is an important
enabling step for disease modeling and drug discovery. Recent advances in tissue …
enabling step for disease modeling and drug discovery. Recent advances in tissue …
Recent advances in liposome surface modification for oral drug delivery
Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration.
Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated …
Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated …
Prodrugs: a challenge for the drug development
JB Zawilska, J Wojcieszak, AB Olejniczak - Pharmacological reports, 2013 - Springer
It is estimated that about 10% of the drugs approved worldwide can be classified as
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …
Carbon dots as advanced drug-delivery nanoplatforms for antiinflammatory, antibacterial, and anticancer applications: A Review
J Qi, R Zhang, X Liu, Y Liu, Q Zhang… - ACS Applied Nano …, 2023 - ACS Publications
Carbon dots (CDs), as rapidly developing nanomaterials, give new prospects for the
treatment of various diseases. Their great biocompatibility and wide specific surface area …
treatment of various diseases. Their great biocompatibility and wide specific surface area …