Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

Oxygen molecules accept electrons from the respiratory chain in the mitochondria and are
responsible for energy production in aerobic organisms. The reactive oxygen species …

Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide
and glutathione persulfide, are endogenously produced in abundance in both prokaryotes …

Methylmercury (MeHg) is a widely known environmental pollutant that causes severe
neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including …

Significance: Polysulfide species (ie, RS nR′, n> 2; and RS nH, n> 1) exist in many
organisms. The highly nucleophilic nature of hydropersulfides and hydropolysulfides …

Significance: Routine exposure to xenobiotics is unavoidable during our lifetimes. Certain
xenobiotics are hazardous to human health, and are metabolized in the body to render them …

The physiological importance of reactive sulfur species (RSS) such as cysteine
hydropersulfide (CysSSH) has been increasingly recognized in recent years. We have …

N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been
widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s …

Significance: S-Persulfidation generates persulfide adducts (RSSH) on both small
molecules and proteins. This process is believed to be critical in the regulation of biological …

Cysteine persulfide (CysSSH) and cysteine polysulfides (CysSSnH, n> 1) are cysteine
derivatives that have sulfane sulfur atoms bound to cysteine thiol. Advances in analytical …