Pyrimidine-based heterocyclic compounds are garnering substantial interest due to their
essential role as a class of natural and synthetic molecules. These compounds show a …

Cancer, characterized by uncontrolled cell growth and metastasis, is responsible for nearly
one in six deaths and represents a severe threat to public health worldwide. Chemotherapy …

One of the most sought-after therapeutic targets for treating human cancers is the
phosphoinositide 3-kinase; PI3k is an integral part of the PI3K/protein kinase B signaling …

This study investigates a series of newly synthesized compounds, including
pyridopyrimidine derivatives (9a-g), tricyclic pyridotriazolopyrimidine analogs (18a-d), and …

A series of oxadiazole-based five-membered heterocyclic derivatives was designed and
synthesized with the intent of exclusive cyclo-oxygenase-2 (COX-2) inhibition to acquire anti …

The key starting material, 2-imino-6-phenyl-2, 3-dihydropyrimidin-4 (5H)-one 1, was the
focus of our approach due to the fact that it has an endocyclic active methylene group …

Heterocyclic molecules have fascinated a massive interest in medicinal chemistry. They are
heterocyclic compounds that have gained significance due to their diverse variety of …

Breast cancer is globally associated with majority of the women. Indeed, high estrogen
levels are the most common subtype of breast cancer. Three different classes of estrogen …

Cancer, caused by the failure of the mechanism that controls cell growth and proliferation, is
usually associated with severe health issues. Nowadays, chemotherapy still occupies an …

Anticancer chemotherapeutics are effective weapons for cancer therapy, but the continuous
emergency of multidrug-resistant cancer and the side effects of current available anticancer …