An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

Antibiotics effective against Gram‐negative ESKAPE pathogens are a critical area of unmet
need. Infections caused by these pathogens are not only difficult to treat but finding new …

Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Infections by Gram-negative pathogens represent a major health care issue of growing
concern due to a striking lack of novel antibacterial agents over the course of the last …

With the emerging problem of antimicrobial resistance, the world is facing a slow but
dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly …

Influenza viruses until today are a leading cause of worldwide severe pandemics and
represent a major threat to human and animal health. Although the primary target of …

Passive diffusion across biomembranes is an important mechanism of permeation for
multiple drugs, including antibiotics. However, this process is frequently neglected while …

Crossing the Gram-negative bacterial membrane poses a major barrier to antibiotic
development, as many small molecules that can biochemically inhibit key bacterial …

The healthy human body is inhabited with a large number of bacteria, forming natural flora. It
is even estimated that for a human body, its amount of DNA is less important that its bacterial …