Aberrant sialylation in cancer: therapeutic opportunities

J Munkley - Cancers, 2022 - mdpi.com
Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Targeting tumor glycans for cancer therapy: successes, limitations, and perspectives

N Berois, A Pittini, E Osinaga - Cancers, 2022 - mdpi.com
Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays
crucial roles in tumor development and biology. Cancer progression can be regulated by …

The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases

A Harduin-Lepers - Glycoconjugate Journal, 2023 - Springer
Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential
roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of …

Abnormal glycosylation in glioma: related changes in biology, biomarkers and targeted therapy

J Yue, R Huang, Z Lan, B Xiao, Z Luo - Biomarker Research, 2023 - Springer
Glioma is a rapidly growing and aggressive primary malignant tumor of the central nervous
system that can diffusely invade the brain tissue around, and the prognosis of patients is not …

Roles and inhibitors of FAK in cancer: current advances and future directions

HH Hu, SQ Wang, HL Shang, HF Lv… - Frontiers in …, 2024 - frontiersin.org
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression
in various tumors and is associated with a poor prognosis. FAK activation promotes tumor …

Sialylation: a cloak for tumors to trick the immune system in the microenvironment

X Zhou, K Chi, C Zhang, Q Liu, G Yang - Biology, 2023 - mdpi.com
Simple Summary Tumor cells accumulate sialylation in tissues via the coordination of
sialyltransferases and sialidases. Tumor sialylation can block receptor and ligand binding at …

Tamoxifen modulates the immune landscape of the tumour microenvironment: the paired siglec-5/14 checkpoint in anti-tumour immunity in an in vitro model of breast …

P Wielgat, K Rogowski, R Czarnomysy… - International Journal of …, 2023 - mdpi.com
Since the role of sialome–Siglec axis has been described as a regulatory checkpoint of
immune homeostasis, the promotion of stimulatory or inhibitory Siglec-related mechanisms …

A novel copper-induced cell death-related lncRNA prognostic signature associated with immune infiltration and clinical value in gastric cancer

L Wang, K Xiao, Z Dong, T Meng, X Cheng… - Journal of Cancer …, 2023 - Springer
Background Gastric cancer (GC) is one of the most important malignancies and has a poor
prognosis. Copper-induced cell death, recently termed cuproptosis, may directly affect the …

The role of neuropilin in bone/cartilage diseases

Z Wu, Y Wang, W Liu, M Lu, J Shi - Life Sciences, 2024 - Elsevier
Bone remodeling is the balance between osteoblasts and osteoclasts. Bone diseases such
as osteoporosis and osteoarthritis are associated with imbalanced bone remodeling …

Integrated analysis of TCGA data identifies endoplasmic reticulum stress-related lncRNA signature in stomach adenocarcinoma

Y Gao, H Zhang, X Tian - Oncologie, 2024 - degruyter.com
Objectives To investigaed the role of endoplasmic reticulum stress (ERS)-related long non-
coding RNAs (lncRNAs) in stomach adenocarcinoma (STAD) using TCGA data. Methods …