Mechanisms and regulation of DNA replication initiation in eukaryotes
MW Parker, MR Botchan, JM Berger - Critical reviews in …, 2017 - Taylor & Francis
Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …
The Mcm complex: unwinding the mechanism of a replicative helicase
ML Bochman, A Schwacha - Microbiology and Molecular Biology …, 2009 - Am Soc Microbiol
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …
The minichromosome maintenance replicative helicase
SD Bell, MR Botchan - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is
composed of six distinct, but related, subunits MCM (2–7). The relationship between the …
composed of six distinct, but related, subunits MCM (2–7). The relationship between the …
Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase
AS Brewster, G Wang, X Yu… - Proceedings of the …, 2008 - National Acad Sciences
The minichromosome maintenance protein (MCM) complex is an essential replicative
helicase for DNA replication in Archaea and Eukaryotes. Whereas the eukaryotic complex …
helicase for DNA replication in Archaea and Eukaryotes. Whereas the eukaryotic complex …
A conserved MCM single-stranded DNA binding element is essential for replication initiation
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex
loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase …
loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase …
Haloferax volcanii—a model archaeon for studying DNA replication and repair
P Pérez-Arnaiz, A Dattani, V Smith… - Open Biology, 2020 - royalsocietypublishing.org
The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …
Archaeal DNA replication
DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …
Analysis of the crystal structure of an active MCM hexamer
In a previous Research article, we suggested an MCM helicase activation mechanism, but
were limited in discussing the ATPase domain because it was absent from the crystal …
were limited in discussing the ATPase domain because it was absent from the crystal …
Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding
BW Graham, GD Schauer, SH Leuba… - Nucleic acids …, 2011 - academic.oup.com
The minichromosome maintenance (MCM) helicase complex is essential for the initiation
and elongation of DNA replication in both the eukaryotic and archaeal domains. The …
and elongation of DNA replication in both the eukaryotic and archaeal domains. The …
G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex
Y Ishimi, D Irie - The journal of biochemistry, 2015 - academic.oup.com
A number of gene mutations are detected in cells derived from human cancer tissues, but
roles of these mutations in cancer cell development are largely unknown. We examined …
roles of these mutations in cancer cell development are largely unknown. We examined …