Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Background In many countries of the industrialised world second generation (" atypical")
antipsychotics have become the first line drug treatment for people with schizophrenia. The …

Background: Debate continues about the comparative benefits and harms of first-generation
antipsychotics (FGAs) and second-generation antipsychotics (SGAs) in treating …

The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Background Endophenotypes are quantitative, laboratory-based measures representing
intermediate links in the pathways between genetic variation and the clinical expression of a …

Background In many countries of the industrialised world second‐generation (" atypical")
antipsychotics (SGAs) have become the first line drug treatment for people with …

Prepulse inhibition (PPI) of the startle response is an important measure of information
processing deficits and inhibitory failure in schizophrenia patients. PPI is especially useful …

Background Startle inhibition by weak prepulses (PPI) is studied to understand the biology
of information processing in schizophrenia patients and healthy comparison subjects (HCS) …

Deficits in empathy, the ability to share an emotion of another individual, constitute a
hallmark of several psychopathological conditions, including conduct disorder. The co …

Prepulse inhibition (PPI) refers to a reduction in the amplitude of the startle eyeblink reflex to
a strong sensory stimulus, the pulse, when it is preceded shortly by a weak stimulus, the …