The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway
constitute the fulcrum in many vital cellular processes, including cell growth, differentiation …

Cytokines and growth factors regulate multiple aspects of cell growth through their
interactions with specific receptors. These receptors initiate signals directed at both the …

Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth
factor receptors. A targeted inactivation of Jak2 was performed. Jak2−/− embryos are anemic …

Many cell functions are regulated by members of the cytokine receptor superfamily.
Signalling by these receptors depends upon their association with Janus kinases (JAKs) …

Cytokines manifest their function through alteration of gene expression. However, target
genes for signals from cytokine receptors are largely unknown. We therefore searched for …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and
activators of transcription) 1 and 3 are activated in response to interleukin‐6 (IL‐6) in human …

Many members of the cytokine receptor superfamily initiate intracellular signaling by
activating members of the Jak family of tyrosine kinases. Activation of the same Jaks by …